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| Field | Last updated |
|---|---|
| Aliases | Fragment 176-191, hGH Frag 176-191, AOD-9604, hGH lipolytic fragment |
| Category | Metabolic |
| Formula | C₇₈H₁₂₃N₂₃O₂₃S₂ |
| Molecular weight | 1815.07 Da |
| Half-life | ~30 min (SC) |
| Mechanism (summary) | AOD9604 (Fragment 176-191) is a synthetic analog derived from the C-terminal lipolytic region of human growth hormone, originally explored as an anti-obesity agent. Preclinical work supports adipose-centered lipolysis through β-adrenergic signaling, but human efficacy data have been inconsistent across development programs. |
| Dosing notes | Human reports include 1 mg/day SC in a 12-week obesity RCT and oral tolerability studies at 9, 27, and 54 mg. Older preclinical work also used 500 μg/kg/day orally in rodents and chronic IP dosing in obese mice. No modern consensus clinical regimen exists. |
| Storage | Peer-reviewed stability data were not retrieved. Practical storage guidance in the accessible literature is largely absent; general research-peptide practice is to store lyophilized material cold, dry, and protected from light, with frozen long-term storage preferred. |
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| Read more | Full reference → |
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