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CJC-1295 DAC

Field	CJC-1295 DAC × Last updated 2 months ago
Aliases	CJC1295 DAC, CJC-1295 with DAC, DAC-GRF, Drug Affinity Complex GHRH analog, modified GHRH(1-29)
Category	Growth Hormone Secretagogues
Formula	C₁₆₅H₂₆₉N₄₇O₄₆
Molecular weight	3647.31 Da
Half-life	~6–8 days (DAC-mediated albumin binding)
Mechanism (summary)	CJC-1295 DAC is a modified GHRH(1-29) analog engineered with a Drug Affinity Complex that covalently binds serum albumin after injection, extending its half-life to roughly 6–8 days. The retrieved literature includes randomized placebo-controlled ascending-dose trials in healthy humans showing sustained GH and IGF-1 elevation with preserved pulsatility.
Dosing notes	Human studies used subcutaneous administration in single ascending doses (30–60 μg/kg best supported) and in weekly or biweekly repeated dosing schedules. More granular cohort doses were not visible in the retrieved abstract; treat any single specific microgram-per-kilogram value as study-protocol level, not consensus clinical dosing.

Storage	Research supplier data are consistent with frozen storage. One Sigma-linked listing reports -80/-20 °C storage with shipping at 4 °C; other CJC-1295 DAC product pages list lyophilized storage at -20 °C and 4 °C after reconstitution, advising against repeated freeze-thaw cycles. These are vendor-level handling instructions, not peer-reviewed pharmaceutical stability.