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| Field | Last updated |
|---|---|
| Aliases | Lumixyl, P4 oligopeptide, Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr |
| Category | Skin & Hair |
| Formula | C₆₈H₉₁N₁₇O₁₈ |
| Molecular weight | 1438.6 Da |
| Half-life | topical (negligible systemic absorption) |
| Mechanism (summary) | Decapeptide-12 is a synthetic 10-amino-acid skin-brightening peptide (commercialized as Lumixyl) that acts as a competitive tyrosinase inhibitor with low melanocyte cytotoxicity in reported assays. Small uncontrolled or split-face clinical studies in melasma and photodamage show modest brightening with a favorable irritation profile relative to hydroquinone. |
| Dosing notes | The peptide is used topically, not systemically. Most consistent regimen is 0.01% cream applied twice daily, often combined with sunscreen and glycolic acid. One procedural report on post-inflammatory hyperpigmentation delivered a 0.01% solution during four SilkPeel dermalinfusion treatments two weeks apart, with twice-daily cream between visits. Systemic-use safety margins are not established. |
| Storage | Storage guidance is supplier-specific. MedChemExpress lists sealed dry storage with powder at -80 °C for 2 years or -20 °C for 1 year. A cosmetic raw-material sheet from ExperChem lists 4 °C, dark and clean storage with a 6-month shelf life. Manufacturer-specific instructions should govern actual laboratory handling. |
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| Read more | Full reference → |
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