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| Field | Last updated |
|---|---|
| Aliases | N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, PNB-0408, AngIV analogue, HGF/c-Met positive modulator |
| Category | Cognitive & Nootropic |
| Formula | C₂₆H₄₃N₃O₅ |
| Molecular weight | 477.64 Da |
| Half-life | hours (oral bioavailable) |
| Mechanism (summary) | Dihexa is a synthetic angiotensin IV (AngIV) analogue reported to be orally active and able to penetrate the blood-brain barrier. The accessed literature does not provide evidence of approved human use and does not identify a human clinical development dataset; evidence status is therefore best described as preclinical. |
| Dosing notes | Human dosing is unspecified. Secondary research summaries of animal work report oral 2 mg/kg, intraperitoneal doses up to 20 mg/kg, intravenous doses up to 10 mg/kg, and intracerebroventricular doses up to 1 nmol. These are animal-research regimens, not clinical recommendations. |
| Storage | Unspecified in the authoritative sources reviewed. Research-grade peptide handling: lyophilized storage at -20°C or colder, protected from light and moisture; aliquot after reconstitution. |
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| Read more | Full reference → |
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