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DSIP

Field	DSIP × Last updated 2 months ago
Aliases	Delta sleep-inducing peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, CAS 62568-57-4
Category	Mood & Stress
Formula	C₃₅H₄₈N₁₀O₁₅
Molecular weight	848.83 Da
Half-life	~7 min
Mechanism (summary)	Delta sleep-inducing peptide (DSIP) is a nonapeptide first described in the 1970s with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. Reviews still describe it as "a still unresolved riddle": the endogenous precursor is unknown, the receptor system is undefined, and the physiological role is incompletely established despite decades of work.
Dosing notes	The most concrete retrieved human dose is 25 nmol/kg IV administered in the afternoon before three monitored sleep nights in chronic insomnia. Older publications describe repeated injections over 4 to 10 administrations, but accessible abstracts do not provide a universally accepted human regimen. Modern safety margins are unspecified.

Storage	Phoenix Pharmaceuticals lists DSIP as soluble in water and recommends storage up to 6 months lyophilized at 0–5 °C. After rehydration: up to 5 days at 4 °C or up to 3 months at -20 °C, with aliquoting to avoid repeated freeze-thaw cycles. Supplier guidance, not a peer-reviewed stability study.