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| Field | Last updated |
|---|---|
| Aliases | GHK, Gly-His-Lys, glycyl-L-histidyl-L-lysine, Tripeptide-1 |
| Category | Healing & Repair |
| Formula | C₁₄H₂₄N₆O₄ |
| Molecular weight | 340.38 Da |
| Half-life | ~few minutes (plasma); used topically |
| Mechanism (summary) | GHK Basic is the free tripeptide Gly-His-Lys, an endogenous copper-binding peptide found in human tissues and plasma. Its defining feature is high-affinity binding of Cu(II), and most of its biology is interpreted through that copper-delivery behavior and its more heavily studied complex, GHK-Cu. |
| Dosing notes | No standardized human therapeutic or research dose was identified for free GHK. In practical laboratory use GHK is handled as a solid reagent and dissolved into stock solution before in vitro work. One commercial Tripeptide-1 technical data sheet describes a transparent pale-yellow liquid containing 1000 ppm (0.1%) Tripeptide-1, which is a raw-material concentration and not a validated therapeutic dose. |
| Storage | Cayman Chemical's product insert lists GHK as a solid stored at -20 C with stated stability of at least 4 years. Stock solutions can be prepared in a chosen solvent, and the insert recommends purging with inert gas during solution preparation. Finished cosmetic Tripeptide-1 solutions remain formulation-specific and should follow the actual supplier's instructions. |
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| Read more | Full reference → |
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