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| Field | Last updated |
|---|---|
| Aliases | hGH, rhGH, Somatropin, Omnitrope, Norditropin, Genotropin, Humatrope |
| Category | Growth Hormone Secretagogues |
| Formula | C₉₉₀H₁₅₃₂N₂₆₂O₃₀₀S₇ |
| Molecular weight | 22124 Da |
| Half-life | ~20–30 min (IV); 2–3 hours (SC) |
| Mechanism (summary) | "Human growth hormone" in modern therapeutics refers to recombinant somatropin. Approved somatropin products such as Omnitrope cover pediatric growth hormone deficiency, Prader–Willi syndrome, small-for-gestational-age children, Turner syndrome, idiopathic short stature, and adult growth hormone deficiency. It is one of the most well-characterized peptide hormone therapies in modern endocrinology. |
| Dosing notes | Pediatric dosing is indication-specific: 0.16–0.24 mg/kg/week for pediatric GHD, 0.24 mg/kg/week for Prader–Willi, up to 0.48 mg/kg/week for SGA, 0.33 mg/kg/week for Turner syndrome, and up to 0.47 mg/kg/week for idiopathic short stature — each divided into 6–7 subcutaneous injections weekly. Adults start at ≤0.04 mg/kg/week or about 0.15–0.30 mg/day, with titration to clinical response and IGF-1. |
| Storage | Omnitrope is refrigerated at 2-8°C, protected from light, and not frozen. Cartridges are generally discarded after 28 days of in-use refrigeration. Reconstituted 5.8 mg vials are used within 21 days; the solution should be swirled gently, not shaken. Storage details vary by brand — always defer to the specific somatropin label in use. |
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| Read more | Full reference → |
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