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| Field | Last updated |
|---|---|
| Aliases | Spadin analog, PE 22-28, TREK-1 inhibitor peptide, Shortened spadin |
| Category | Mood & Stress |
| Formula | C₃₇H₅₉N₉O₁₄ |
| Molecular weight | 854 Da |
| Half-life | ~hours (preclinical) |
| Mechanism (summary) | PE-22-28 is a shortened analog derived from the spadin program, developed around inhibition of the TREK-1 potassium channel — a target implicated in depression biology. The retrievable indexed literature is preclinical rather than clinical. |
| Dosing notes | There is no established human dosing standard for PE-22-28 and no approved product label. Preclinical research uses injection routes appropriate to the animal model under study. |
| Storage |
No product-specific validated storage standard was identified. Standard laboratory peptide handling applies: dry and frozen storage, light and moisture protection, minimal freeze-thaw after reconstitution. |
| Read more | Full reference → |
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