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| Field | Last updated |
|---|---|
| Aliases | Leuphasyl, Tyr-D-Ala-Gly-Phe-Leu, Pentapeptide-3 (older INCI name in original Lipotec dossier) |
| Category | Skin & Hair |
| Formula | C₂₈H₃₇N₅O₇ |
| Molecular weight | 555.62 Da |
| Half-life | topical (negligible systemic absorption) |
| Mechanism (summary) | Pentapeptide-18 (trade name Leuphasyl) is a cosmetic anti-wrinkle peptide with the sequence Tyr-D-Ala-Gly-Phe-Leu, marketed as an enkephalin-mimetic. The original Lipotec dossier used the older proposed INCI name "Pentapeptide-3", a nomenclature inconsistency worth flagging — the molecule is the same. |
| Dosing notes | Topical application only. Manufacturer guidance: 3–10% of the commercial solution in finished formulations; add below 40 °C. Volunteer-study regimen used 5% of the commercial solution applied twice daily around the eyes for 28 days. No therapeutic or systemic dose is established. |
| Storage | Manufacturer stability data: cool, dark, clean storage with at least 12 months shelf life; storage at 4 °C extends shelf life to at least 18 months. Treat as supplier guidance — not a peer-reviewed pharmaceutical stability study. |
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| Read more | Full reference → |
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