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Compare peptides · AminoCatalog

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Protirelin

Field	Protirelin × Last updated 2 weeks ago
Aliases	TRH, thyrotropin-releasing hormone, synthetic TRH, Thypinone (historical)
Category	Other Research Peptides
Formula	C₁₆H₂₂N₆O₄
Molecular weight	362.39 Da
Half-life	~5 min (IV)
Mechanism (summary)	Protirelin is synthetic thyrotropin-releasing hormone (TRH). Historically used as a diagnostic pituitary-thyroid challenge agent. Current U.S. public labeling on DailyMed reflects a compounded product, and PubChem notes protirelin is not currently available in an FDA-approved product.
Dosing notes	Adult diagnostic dose: 500 mcg IV bolus over 15–30 seconds with the patient supine (200–500 mcg range used). Pediatric: 7 mcg/kg up to 500 mcg. Baseline and 30-minute TSH sampling are standard. Repeat testing should generally wait at least 7 days.