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| Field | Last updated |
|---|---|
| Aliases | Protein Transduction Domain-Dishevelled Binding Motif, CXXC5-Dvl interaction antagonist |
| Category | Skin & Hair |
| Formula | — |
| Molecular weight | — |
| Half-life | — |
| Mechanism (summary) | PTD-DBM is a synthetic, cell-penetrating competitor peptide engineered to disrupt the CXXC5-Dishevelled (Dvl) protein-protein interaction. By displacing CXXC5 — a negative feedback regulator of Wnt — it reactivates Wnt/β-catenin signaling and downstream wound-healing and follicle-regeneration programs. No human clinical data identified. |
| Dosing notes | No validated human dose. Preclinical work used 2 or 10 μM in fibroblast culture and topical 10 mM every other day in mouse hair-loss models. Human pharmacokinetics are not established. |
| Storage |
No authoritative clinical storage monograph exists. Any vendor-specific reconstitution rule should be treated as supplier-specific rather than authoritative. |
| Read more | Full reference → |
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