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| Field | Last updated |
|---|---|
| Aliases | Geref, GHRH(1-29)NH2, GRF(1-29)NH2, sermorelin acetate |
| Category | Growth Hormone Secretagogues |
| Formula | C₁₄₉H₂₄₆N₄₄O₄₂S |
| Molecular weight | 3357.93 Da |
| Half-life | ~11–12 min (IV) |
| Mechanism (summary) | Sermorelin is a synthetic analog of the first 29 amino acids of human growth hormone-releasing hormone (GHRH(1-29)NH2). It was FDA-approved as Geref for both GH-reserve diagnostic testing and pediatric growth hormone deficiency treatment; the FDA documented that the products were later withdrawn from sale, but not for reasons of safety or effectiveness. |
| Dosing notes | Diagnostic use: 1.0 μg/kg IV once after overnight fast. Historical pediatric treatment: 30 μg/kg/day SC at bedtime. Both regimens come from approved-product labeling. |
| Storage |
Per Geref label: store at 2–8 °C, protect from light, shelf life 2 years. Reconstitute immediately before use and discard remainder. |
| Read more | Full reference → |
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