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Tirzepatide

Field	Tirzepatide × Last updated 2 months ago
Aliases	Mounjaro, Zepbound, LY3298176, GIP/GLP-1 dual agonist, twincretin
Category	Metabolic
Formula	C₂₂₅H₃₄₈F₂N₄₈O₆₈
Molecular weight	4813.45 Da
Half-life	~5 days
Mechanism (summary)	Tirzepatide is the active ingredient in Mounjaro and Zepbound. It is an FDA-approved synthetic peptide that activates both GIP and GLP-1 receptors. The current Zepbound label covers chronic weight management and moderate-to-severe obstructive sleep apnea in adults with obesity; Mounjaro is approved for type 2 diabetes. Tirzepatide products were first approved in the U.S. in 2022.
Dosing notes	Zepbound starts at 2.5 mg subcutaneously once weekly for 4 weeks, then 5 mg, with further 2.5 mg increments after at least 4 weeks on each dose. Recommended maintenance: 5, 10, or 15 mg weekly for weight management and 10 or 15 mg weekly for OSA. Maximum labeled dose 15 mg weekly. Do not coadminister with other tirzepatide-containing products or any GLP-1 receptor agonist. Counsel on oral-contraceptive interaction for 4 weeks after initiation and after each escalation.

Storage	Single-dose pens and vials are stored at 2-8°C, protected from light, and may be kept unrefrigerated below 30°C for up to 21 days. Multi-dose vials and the single-patient KwikPen are refrigerated before use, can sit at room temperature for up to 30 days, and once opened are discarded after 30 days, after 4 weekly doses, or after a total of 30 days at room temperature, whichever comes first. Do not freeze.

Storage

Single-dose pens and vials are stored at 2-8°C, protected from light, and may be kept unrefrigerated below 30°C for up to 21 days. Multi-dose vials and the single-patient KwikPen are refrigerated before use, can sit at room temperature for up to 30 days, and once opened are discarded after 30 days, after 4 weekly doses, or after a total of 30 days at room temperature, whichever comes first. Do not freeze.