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| Field | Last updated |
|---|---|
| Aliases | Vasoactive Intestinal Peptide, aviptadil, Zyesami, synthetic VIP |
| Category | Other Research Peptides |
| Formula | C₁₄₇H₂₃₇N₄₃O₄₃S |
| Molecular weight | 3326.79 Da |
| Half-life | ~1–2 min (IV) |
| Mechanism (summary) | VIP is an endogenous neuropeptide with broad vasoactive, pulmonary, gastrointestinal, and immunomodulatory functions. The main synthetic therapeutic analog in the literature is aviptadil (Zyesami). It remains investigational in the U.S. rather than FDA-approved. |
| Dosing notes | No standard FDA-approved VIP dose. Published aviptadil IV protocols in severe respiratory failure used three escalating infusions over successive days at 50, 100, and 150 pmol/kg/hour over 12 hours (approximately 0.166, 0.332, and 0.498 mcg/kg/hour). Investigational regimens, not general-use dosing. |
| Storage | For a publicly described aviptadil injection product: storage refrigerated at 2–8 °C, protected from freezing. |
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| Read more | Full reference → |
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