Epithalon

Longevity

aka Epitalon · Epithalone · Ala-Glu-Asp-Gly

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Formula

MW (Da)

Half-life

~few minutes (short tetrapeptide)

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Overview

Epithalon (Epitalon, AEDG) is a synthetic tetrapeptide developed as a defined analog related to epithalamin, a pineal polypeptide preparation. The compound is best known in the Khavinson gerontology literature; modern independent human trial evidence is sparse, and the strongest data remain cellular.

Mechanism

The most-cited mechanistic claim is telomere biology. A 2003 paper reported that Epithalon induces telomerase activity and telomere elongation in human somatic cells. Subsequent reviews describe broader gene-expression effects, including promoter interactions and possible neuroendocrine and antioxidant actions. Reviews note the peptide was long treated as a synthetic construct, then reported in physiological pineal extract in 2017. Modern human pharmacokinetics were not retrieved.

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Reported benefits

Telomerase induction and telomere elongation in human somatic cells

A 2003 paper reported that Epithalon induces telomerase activity and elongates telomeres in human somatic cells — the most-cited mechanistic data for the compound.

[epithalon-telomerase-2003]

preclinical

Older reports of geroprotective and retinal effects

Reviews summarize geroprotective, retinal, and pineal effects from older studies. Modern independent randomized human trials of the synthetic tetrapeptide were not retrieved.

[epithalon-pubmed-review]

preclinical

Reported side effects

Limited safety data for the synthetic tetrapeptide
anecdotal
Direct modern Epithalon adverse-event incidence data were not retrieved. Side-effect frequency and severity for the tetrapeptide itself remain insufficiently characterized.
Favorable older epithalamin trial signals (different molecule)
clinical
An Alzheimer's Drug Discovery Foundation brief states two 3-year epithalamin treatment trials reported no severe adverse events in older adults, but the brief emphasizes the need for independent validation and explicitly distinguishes epithalamin from Epithalon.

Dosing notes

A modern reproducible human dosing standard was not retrievable from accessible primary sources. Historical Russian-language cyclic regimens are mentioned in reviews but accessible sources do not provide a standardized contemporary human regimen with validated safety margins.

Research use only. Information on this page is editorial reference, not medical or dosing advice. Always consult qualified medical guidance before use.

Storage

Supplier datasheets recommend frozen storage. One technical sheet specifies -20 °C before reconstitution, protected from light, and 4 °C after reconstitution. Another supplier lists powder at -20 °C up to 3 years and solution at -80 °C for 1 year. Practical research-handling notes only, not peer-reviewed stability studies.

Vendors carrying Epithalon

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References

[epithalon-telomerase-2003]
Epithalon induces telomerase activity and elongates telomeres in human somatic cells
Khavinson VK et al. · 2003 · PubMed
Source
[epithalon-pubchem]
Epitalon (PubChem)
PubChem (NIH) · PubChem
Source
[epithalon-addf-brief]
Epithalamin and Epithalon — Cognitive Vitality for Researchers brief
Alzheimer's Drug Discovery Foundation · Alzheimer's Drug Discovery Foundation researcher brief
Source
[epithalon-pubmed-review]
Epithalon mechanistic and gerontology review
Review authors per PubMed entry · PubMed (review)
Source
[epithalon-tds]
Epitalon technical data sheet (storage and handling)
Vendor technical data sheet · Supplier technical data sheet
Source