GHRP-6

Growth Hormone Secretagogues

aka GHRP6 · Growth Hormone Releasing Peptide 6 · His-D-Trp-Ala-Trp-D-Phe-Lys-NH2

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Formula

MW (Da)

Half-life

~15–60 min

Saves

Overview

GHRP-6 is a synthetic GH secretagogue hexapeptide (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, MW 872.44 Da). In humans it is concentrated in endocrine challenge tests, diagnostic protocols, and mechanistic studies — particularly as part of the GHRH/GHRP-6 test for adult GH deficiency — rather than in therapeutic outcome trials.

Mechanism

GHRP-6 acts as a ghrelin receptor agonist, increasing GH secretion and also affecting appetite and GI motility. In humans, endogenous GHRH is necessary for most of the GH response to GHRP-6, which is a key mechanistic distinction from direct pituitary stimulation. Preclinical work also supports appetite and prokinetic GI effects.

Reported benefits

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Diagnostic value in adult GH deficiency (GHRH/GHRP-6 test)

The GHRH/GHRP-6 test is reported as a convenient, safe, and reliable diagnostic test for adult GH deficiency, with mechanistic human studies commonly using 1 μg/kg IV alone or with GHRH.

[ghrp6-diagnostic]

clinical

Safe IV scale-up in healthy volunteers

Review literature states that intravenous GHRP-6 was safe in a dose scale-up trial in healthy volunteers; therapeutic-efficacy data for chronic disease states remain limited.

[ghrp6-safety-pmc]

clinical

Reported side effects

Acute safety reported in short-term human challenge studies
clinical
Short-term human challenge studies and review summaries describe GHRP-6 as safe in the settings studied. Detailed modern adverse-event incidence tables were not retrieved here.
Long-term therapeutic safety insufficiently characterized
anecdotal
Most human studies were short and physiologic; long-term therapeutic safety remains insufficiently characterized.

Dosing notes

Best-supported accessible human dosing is 1 μg/kg IV, used in mechanistic and diagnostic testing — alone or combined with GHRH 1 μg/kg IV. These are test paradigms, not chronic therapeutic regimens.

Research use only. Information on this page is editorial reference, not medical or dosing advice. Always consult qualified medical guidance before use.

Storage

Primary publications did not provide GHRP-6-specific stability instructions in the retrieved literature. Generic peptide handling practice favors cold, dry storage of lyophilized material and avoidance of repeated freeze-thaw cycles after reconstitution.

Vendors carrying GHRP-6

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Discussion

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References

[ghrp6-pk-pubmed]
GHRP-6 pharmacokinetic characterization (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2)
Authors per PubMed entry · PubMed
Source
[ghrp6-mechanism-pubmed]
GHRP-6 mechanism in humans: dependence on endogenous GHRH
Authors per PubMed entry · PubMed
Source
[ghrp6-diagnostic]
GHRH/GHRP-6 test for adult GH deficiency
Authors per PubMed entry · PubMed
Source
[ghrp6-safety-pmc]
GHRP-6 dose scale-up safety in healthy volunteers (review)
Review authors per PMC entry · PubMed Central
Source

Diagnostic value in adult GH deficiency (GHRH/GHRP-6 test)

Safe IV scale-up in healthy volunteers

Acute safety reported in short-term human challenge studies

Long-term therapeutic safety insufficiently characterized

Discussion