NAD+

Longevity

aka Nicotinamide adenine dinucleotide · NAD · beta-NAD

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Formula

MW (Da)

Half-life

minutes (IV infusion); rapid metabolic turnover

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Overview

NAD+ is a coenzyme — not a peptide. It is central to redox metabolism and serves as a substrate for enzymes tied to DNA repair, stress responses, and aging biology, including PARPs and sirtuins. Included here for completeness from the source dossier. The "longevity" reputation is well ahead of the controlled clinical evidence.

Mechanism

Mechanistically the case for NAD+ is strong at the biochemical level. The translational case is much weaker. Recent reviews conclude that NAD+ augmentation clearly changes biology, and oral precursors such as NR, NMN, and NAM reliably raise NAD-related biomarkers in humans — but clinical benefits for anti-aging, metabolic, vascular, or performance outcomes remain mixed or inconclusive. Importantly, a recent review found no eligible outcomes trials testing direct IV or IM NAD+ for anti-aging or general wellness, so many popular claims run ahead of the evidence.

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Reported benefits

Oral precursors raise NAD biomarkers reliably

Oral NAD precursors (NR, NMN, NAM) reliably raise NAD-related biomarkers in humans — a biochemical change that does not by itself prove clinical benefit.

[nad-pubmed-review]

clinical

No outcomes trials of direct IV/IM NAD+ for anti-aging

A recent review found no eligible outcomes trials testing direct IV or IM NAD+ for anti-aging or general wellness — meaning popular wellness claims about NAD+ drips run ahead of controlled evidence.

[nad-pubmed-review]

clinical

Central biochemical role in repair, stress, and metabolism

NAD+ is a substrate for PARPs and sirtuins, central to DNA repair and stress responses; the biochemistry is solid even where clinical outcomes are not.

[nad-pmc-biology]

preclinical

Reported side effects

IV-infusion side effects: GI upset, increased heart rate, chest pressure
clinical
A 2026 IV study reported moderate to severe gastrointestinal symptoms, increased heart rate, and chest pressure in NAD+-infusion participants; some NR-IV comparator subjects had tingling and cramping.
Mixed adverse effects across NAD-related interventions
clinical
A 2024 review of NAD-related interventions also found reported adverse effects across studies, including muscle pain, fatigue, nervous-system complaints, and sleep disturbances.

Dosing notes

No consensus direct-NAD+ human wellness dose is both standardized and strongly evidence-based. Most higher-quality human data still concern oral precursors (NR, NMN, NAM) rather than infused NAD+ itself.

Research use only. Information on this page is editorial reference, not medical or dosing advice. Always consult qualified medical guidance before use.

Storage

For research-grade NAD+, supplier and reagent data commonly specify -20°C storage for powder and aqueous stock solutions. Finished IV-clinic preparations should follow the pharmacy's labeling.

Vendors carrying NAD+

No approved vendors are listing this peptide yet. Check back later or browse the full vendor directory.

Discussion

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References

[nad-pmc-biology]
NAD+ in aging biology and PARP/sirtuin signaling (PMC review)
Review authors per PMC entry · PubMed Central
Source
[nad-pubmed-review]
NAD+ augmentation evidence review (no eligible IV/IM trials)
Authors per PubMed entry · PubMed
Source
[nad-pubmed-iv2026]
2026 IV NAD+ infusion study — adverse-effect characterization
Authors per PubMed entry · PubMed
Source
[nad-pmc-2024review]
2024 review of NAD-related interventions and adverse effects
Review authors per PMC entry · PubMed Central
Source
[nad-sigma]
NAD+ research-grade storage data (Sigma-Aldrich N8410)
Sigma-Aldrich · Sigma-Aldrich
Source