Humanin

Longevity

aka HN · HNG (Humanin analog) · S14G-Humanin

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Formula

MW (Da)

Half-life

hours

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Overview

Humanin is a small endogenous mitochondrial-derived peptide with a remarkable preclinical portfolio in apoptosis resistance, neuroprotection, metabolic regulation, and ischemia-reperfusion injury. Translated human clinical evidence remains very limited.

Mechanism

Humanin operates through at least two mechanistic modes. Intracellularly, it inhibits apoptosis by interfering with Bax activation and mitochondrial membrane insertion. Extracellularly, it signals through a trimeric CNTFR / WSX-1 / gp130 receptor complex, and other studies have connected Humanin-family signaling to formyl peptide receptor-like pathways. The integrated consequence is activation of pro-survival signaling, often described via STAT3, ERK, and related anti-apoptotic cascades.

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Reported benefits

Neuroprotection and cognitive effects in animal models

Humanin analogs improved cognitive or metabolic outcomes in Alzheimer-related mouse models. The strongest efficacy data remain animal and in vitro.

[humanin-review-2005]

preclinical

Cardioprotection in large-animal MI/R

The potent analog HNG reduced infarct size in a large-animal myocardial ischemia-reperfusion model. Biologically interesting but not a substitute for human trials.

[hng-large-animal-mir]

preclinical

Reported side effects

Human adverse-event incidence unknown
anecdotal
Interventional human exposure is essentially uncharacterized, so human adverse-event incidence is not established.
Preclinical tumor-promotion caution
preclinical
A preclinical breast-cancer study found that Humanin promoted tumor progression and chemoresistance, suggesting its anti-apoptotic activity may cut both ways depending on context.

Dosing notes

No standardized human research dose is available from the retrieved literature. Representative animal dosing includes S14G-Humanin 0.4 mg/kg/day intraperitoneally for 16 weeks in diabetic rats and HNG 2 mg/kg in a large-animal MI/R setting. These illustrate the preclinical scale but should not be treated as translatable human dosing.

Research use only. Information on this page is editorial reference, not medical or dosing advice. Always consult qualified medical guidance before use.

Storage

A current supplier datasheet states that lyophilized Humanin is stable at room temperature for short transit periods but should be stored desiccated below -18 C. After reconstitution it should be kept at 4 C for 2-7 days and below -18 C for longer storage, ideally with 0.1% HSA or BSA to reduce adsorption, while avoiding freeze-thaw cycles.

Vendors carrying Humanin

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Discussion

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References

[humanin-review-2005]
Humanin: a peptide preventing neuronal cell death (review)
Review · PubMed (review)
Source
[humanin-breast-cancer]
Humanin promotes breast-cancer progression and chemoresistance
Authors per Nature Sci Rep · 2020 · Scientific Reports
Source
[hng-large-animal-mir]
HNG reduces infarct size in large-animal MI/R
Authors per PubMed entry · PubMed
Source
[humanin-overview-pmc]
Humanin: overview of mitochondrial-derived peptide biology
Review · PubMed Central
Source
[prospec-humanin]
Humanin recombinant protein datasheet and stability
ProSpec Bio · ProSpec product page
Source