Peptide directory

Kisspeptin-10 is a short active fragment of kisspeptin and functions as a physiologic upstream trigger of GnRH secretion. Its human evidence is compelling at the level of acute endocrine activation, but far less developed for standardized long-term clinical use.

KPV is the tripeptide Lys-Pro-Val, a minimal active fragment from the C-terminus of alpha-MSH. It is one of the more interesting translational anti-inflammatory peptides in gastrointestinal research, but current evidence is overwhelmingly preclinical.

Livagen is a short synthetic tetrapeptide, Lys-Glu-Asp-Ala (KEDA), from the Khavinson "bioregulator" literature. It is studied mainly as a liver-associated peptide, with most indexed work in Russian and centered on chromatin effects, liver morphology, and broader organ bioregulation rather than modern large clinical trials.

LL-37 is the only human cathelicidin antimicrobial peptide — an endogenous host-defense molecule that sits at the intersection of innate immunity, biofilm control, inflammation, and tissue repair. It has both protective and potentially pro-inflammatory effects, so its literature is unusually dual-sided.

In this report, Matrixyl refers to palmitoyl pentapeptide-4 — the original Matrixyl active. It is a synthetic signal peptide (matrikine) developed for anti-wrinkle cosmetics. Matrixyl 3000 is a different commercial complex built around palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7, which this catalog covers separately under Pal-GHK.

Mazdutide (IBI362, LY3305677) is a once-weekly synthetic oxyntomodulin analogue with a fatty-acyl moiety for extended exposure. It is a dual GLP-1R / GCGR agonist. Innovent has reported NMPA approval in China for chronic weight management and later for glycemic control in adults with type 2 diabetes; outside China it remains investigational.

Melanotan 1 is best understood clinically as afamelanotide — the active ingredient in SCENESSE, an FDA-approved implant for adults with erythropoietic protoporphyria (EPP). It is not approved as a cosmetic tanning aid.

Melanotan II is a synthetic cyclic analogue of α-melanocyte-stimulating hormone. It has never obtained mainstream regulatory approval and appears in official warnings as an unlicensed or unapproved product. Dosing, purity, sterility, and composition of gray-market products are usually not standardized.

Methylene blue is an oxidation-reduction thiazine dye. In the U.S., PROVAYBLUE is an FDA-approved methylene blue injection for methemoglobinemia. Low-dose mitochondrial or neurocognitive uses are widely discussed elsewhere, but the strongest evidence and clearest regulatory footing remain the approved hematologic indication.

"Mechano-Growth Factor" usually refers to the IGF-1Ec splice variant or, in many peptide products, to synthetic peptides derived from the MGF E-domain. MGF expression rises after mechanical loading, stretch, or injury, but the field has been marked by disputed interpretations and confirmation-bias concerns.

Mod GRF 1-29 is commonly treated as the same molecule as CJC-1295 without DAC — a short-acting, stabilized analog of the active N-terminal portion of GHRH. Peer-reviewed analytical literature identifies the molecule as (D-Ala2, Gln8, Ala15, Leu27)-GRF amide, distinguishing it from longer-acting DAC-containing forms.

MOTS-c is a mitochondrial-derived peptide, not a conventional secretagogue or growth factor. Encoded within mitochondrial 12S rRNA, it has become a major research focus in metabolism, exercise biology, and healthy aging. In animals it behaves like an exercise-responsive metabolic regulator.

N-Acetyl Selank is an acetylated Selank analog. PubChem catalogs the molecule, but direct human clinical literature for the modified form is notably sparse. The functional claims around it are largely extrapolated from the parent peptide Selank — a tuftsin-derived heptapeptide studied in Russian anxiety-related literature.

In research catalogs, this compound is usually called N-Acetyl Semax amidate — a modified version of Semax (an ACTH(4-10)-derived heptapeptide). PubChem identifies the modified molecule, but indexed clinical evidence for the modified form is limited. Most meaningful biological and clinical discussion still comes from the parent peptide Semax.

NAD+ is a coenzyme — not a peptide. It is central to redox metabolism and serves as a substrate for enzymes tied to DNA repair, stress responses, and aging biology, including PARPs and sirtuins. Included here for completeness from the source dossier. The "longevity" reputation is well ahead of the controlled clinical evidence.

Nonapeptide-1 is a synthetic depigmenting peptide used primarily in cosmetics and skin-brightening research. It is framed as a melanogenesis-modulating peptide rather than a repair peptide or nootropic, and works upstream by antagonizing the α-MSH / MC1R axis.

Oxytocin is an endogenous nonapeptide hormone with approved medical use in labor induction, labor augmentation, and postpartum bleeding control (Pitocin). Its sexual-health relevance comes from experimental and translational literature on social bonding, sexual arousal, orgasm, attachment, and pair-related behavior — mostly through intranasal rather than obstetric use.

Pal-AHK is the palmitoylated form of the tripeptide Ala-His-Lys. Direct peer-reviewed literature on the palmitoylated version is very sparse, so most biological rationale comes from broader cosmetic-peptide design principles and from work on the parent AHK or AHK-Cu systems.

Pal-GHK is palmitoyl tripeptide-1 — historically also called palmitoyl oligopeptide. It is a GHK-based signal peptide used in cosmetics and is one of the peptide components associated with Matrixyl 3000-style formulations.

PE-22-28 is a shortened analog derived from the spadin program, developed around inhibition of the TREK-1 potassium channel — a target implicated in depression biology. The retrievable indexed literature is preclinical rather than clinical.

PEG-MGF is a pegylated MGF derivative intended to preserve or extend the activity window of native MGF-like signaling. The design rationale (PEGylation as a half-life-extension strategy) is scientifically reasonable, but that does not mean PEG-MGF itself has a validated human pharmacokinetic or therapeutic profile.

Pentapeptide-18 (trade name Leuphasyl) is a cosmetic anti-wrinkle peptide with the sequence Tyr-D-Ala-Gly-Phe-Leu, marketed as an enkephalin-mimetic. The original Lipotec dossier used the older proposed INCI name "Pentapeptide-3", a nomenclature inconsistency worth flagging — the molecule is the same.

Pinealon is the EDR tripeptide (Glu-Asp-Arg), a Khavinson-school neuroregulatory bioregulator. Russian references list it as a dietary supplement rather than a prescription medicinal product, and it has no FDA or EMA drug approval.

PNC-27 is a 32-residue chimeric p53-derived anticancer peptide that fuses the p53 residues 12–26 HDM-2-binding domain (PPLSQETFSDLWKLL) to a membrane-penetrating / membrane-residency sequence. It selectively binds HDM-2/MDM2 expressed on cancer-cell membranes, induces transmembrane pore formation, and causes necrotic lysis. No human clinical dataset was identified in the source material.