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Editorial entries for every peptide we cover — each page links the vendors that carry it, the reviews users have left, and the literature behind it.
Epithalon (Epitalon, AEDG) is a synthetic tetrapeptide developed as a defined analog related to epithalamin, a pineal polypeptide preparation. The compound is best known in the Khavinson gerontology literature; modern independent human trial evidence is sparse, and the strongest data remain cellular.
FOXO4-DRI is a designed D-retro-inverso peptide built from the FOXO4 interaction surface and engineered to disrupt the FOXO4–p53 axis specifically in senescent cells. It is a research-stage senolytic with no human clinical trials in the retrieved literature.
Humanin is a small endogenous mitochondrial-derived peptide with a remarkable preclinical portfolio in apoptosis resistance, neuroprotection, metabolic regulation, and ischemia-reperfusion injury. Translated human clinical evidence remains very limited.
NAD+ is a coenzyme — not a peptide. It is central to redox metabolism and serves as a substrate for enzymes tied to DNA repair, stress responses, and aging biology, including PARPs and sirtuins. Included here for completeness from the source dossier. The "longevity" reputation is well ahead of the controlled clinical evidence.